WEB-based GEne SeT AnaLysis Toolkit
 
Translating gene lists into biological insights...
 


User data and parameters: User data: textAreaUpload.txt, Organism: hsapiens, Id Type: ensembl_gene_stable_id, Ref Set: entrezgene, Significance Level: Top10, Statistics Test: Hypergeometric, MTC: BH, Minimum: 2

The results for each enriched gene sets are listed in this table.
For each gene set, the first row lists database name, gene set name , and corresponding gene set ID.
The second row lists the following statistics:
Finally, genes in the pathway are listed. For each gene, the table lists the user uploaded ID and value (optional), Entrez ID, Ensembl Gene Stable ID, Gene symbol, and description. Ensembl Gene Stable ID and Entrez Gene ID are linked to the Ensembl and Entrez Gene databases, respectively.

Database:KEGG pathway       Name:Proteasome       ID:03050
C=44; O=10; E=0.12; R=83.77; rawP=3.34e-17; adjP=4.34e-16
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000008018 NA PSMB1 proteasome (prosome, macropain) subunit, beta type, 1 5689 ENSG00000008018
2  ENSG00000100567 NA PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3 5684 ENSG00000100567
3  ENSG00000127922 NA SHFM1 split hand/foot malformation (ectrodactyly) type 1 7979 ENSG00000127922
4  ENSG00000161057 NA PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2 5701 ENSG00000161057
5  ENSG00000115233 NA PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 10213 ENSG00000115233
6  ENSG00000132963 NA POMP proteasome maturation protein 51371 ENSG00000132963
7  ENSG00000041357 NA PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4 5685 ENSG00000041357
8  ENSG00000143106 NA PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5 5686 ENSG00000143106
9  ENSG00000108294 NA PSMB3 proteasome (prosome, macropain) subunit, beta type, 3 5691 ENSG00000108294
10  ENSG00000197170 NA PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 5718 ENSG00000197170


Database:KEGG pathway       Name:Spliceosome       ID:03040
C=127; O=8; E=0.34; R=23.22; rawP=2.36e-09; adjP=1.53e-08
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000139343 NA SNRPF small nuclear ribonucleoprotein polypeptide F 6636 ENSG00000139343
2  ENSG00000143977 NA SNRPG small nuclear ribonucleoprotein polypeptide G 6637 ENSG00000143977
3  ENSG00000125870 NA SNRPB2 small nuclear ribonucleoprotein polypeptide B 6629 ENSG00000125870
4  ENSG00000116752 NA BCAS2 breast carcinoma amplified sequence 2 10286 ENSG00000116752
5  ENSG00000125743 NA SNRPD2 small nuclear ribonucleoprotein D2 polypeptide 16.5kDa 6633 ENSG00000125743
6  ENSG00000124380 NA SNRNP27 small nuclear ribonucleoprotein 27kDa (U4/U6.U5) 11017 ENSG00000124380
7  ENSG00000169976 NA SF3B5 splicing factor 3b, subunit 5, 10kDa 83443 ENSG00000169976
8  ENSG00000162385 NA MAGOH mago-nashi homolog, proliferation-associated (Drosophila) 4116 ENSG00000162385


Database:KEGG pathway       Name:Ubiquitin mediated proteolysis       ID:04120
C=135; O=4; E=0.37; R=10.92; rawP=0.0005; adjP=0.0022
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000184182 NA UBE2F ubiquitin-conjugating enzyme E2F (putative) 140739 ENSG00000184182
2  ENSG00000154582 NA TCEB1 transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C) 6921 ENSG00000154582
3  ENSG00000177889 NA UBE2N ubiquitin-conjugating enzyme E2N 7334 ENSG00000177889
4  ENSG00000131508 NA UBE2D2 ubiquitin-conjugating enzyme E2D 2 7322 ENSG00000131508


Database:KEGG pathway       Name:Ribosome biogenesis in eukaryotes       ID:03008
C=80; O=3; E=0.22; R=13.82; rawP=0.0014; adjP=0.0046
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000105171 NA POP4 processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae) 10775 ENSG00000105171
2  ENSG00000085231 NA TAF9 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa 6880 ENSG00000085231
3  ENSG00000182117 NA NOP10 NOP10 ribonucleoprotein homolog (yeast) 55505 ENSG00000182117


Database:KEGG pathway       Name:Homologous recombination       ID:03440
C=28; O=2; E=0.08; R=26.33; rawP=0.0026; adjP=0.0068
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000106028 NA SSBP1 single-stranded DNA binding protein 1, mitochondrial 6742 ENSG00000106028
2  ENSG00000127922 NA SHFM1 split hand/foot malformation (ectrodactyly) type 1 7979 ENSG00000127922


Database:KEGG pathway       Name:Regulation of autophagy       ID:04140
C=34; O=2; E=0.09; R=21.68; rawP=0.0039; adjP=0.0085
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000144848 NA ATG3 autophagy related 3 64422 ENSG00000144848
2  ENSG00000101844 NA ATG4A autophagy related 4A, cysteine peptidase 115201 ENSG00000101844


Database:KEGG pathway       Name:Basal transcription factors       ID:03022
C=37; O=2; E=0.10; R=19.92; rawP=0.0046; adjP=0.0085
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000085231 NA TAF9 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa 6880 ENSG00000085231
2  ENSG00000140307 NA GTF2A2 general transcription factor IIA, 2, 12kDa 2958 ENSG00000140307


Database:KEGG pathway       Name:RNA transport       ID:03013
C=151; O=3; E=0.41; R=7.32; rawP=0.0082; adjP=0.0133
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000105171 NA POP4 processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae) 10775 ENSG00000105171
2  ENSG00000162385 NA MAGOH mago-nashi homolog, proliferation-associated (Drosophila) 4116 ENSG00000162385
3  ENSG00000116030 NA SUMO1 SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae) 7341 ENSG00000116030


Database:KEGG pathway       Name:Shigellosis       ID:05131
C=61; O=2; E=0.17; R=12.09; rawP=0.0120; adjP=0.0173
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000136950 NA ARPC5L actin related protein 2/3 complex, subunit 5-like 81873 ENSG00000136950
2  ENSG00000131508 NA UBE2D2 ubiquitin-conjugating enzyme E2D 2 7322 ENSG00000131508


Database:KEGG pathway       Name:Oxidative phosphorylation       ID:00190
C=132; O=2; E=0.36; R=5.58; rawP=0.0502; adjP=0.0653
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000128524 NA ATP6V1F ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F 9296 ENSG00000128524
2  ENSG00000180817 NA PPA1 pyrophosphatase (inorganic) 1 5464 ENSG00000180817




WebGestalt is currently developed and maintained by Jing Wang and Bing Zhang at the Zhang Lab. Other people who have made significant contribution to the project include Dexter Duncan, Stefan Kirov, Zhiao Shi, and Jay Snoddy.

Funding credits: NIH/NIAAA (U01 AA016662, U01 AA013512); NIH/NIDA (P01 DA015027); NIH/NIMH (P50 MH078028, P50 MH096972); NIH/NCI (U24 CA159988); NIH/NIGMS (R01 GM088822).